SPC25 Antibody, FITC conjugated

Size

100ug

Clone Number

Aliases

AD024 antibody; hSpc25 antibody; Kinetochore protein Spc25 antibody; SPBC25 antibody; SPC25 antibody; SPC25_HUMAN antibody; spindle pole body component 25 homolog antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9HBM1

Immunogen

Recombinant Human Kinetochore protein Spc25 protein (1-224AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

Background

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

FITC

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SPC25

Research Areas

Epigenetics and Nuclear Signaling; Cell biology