SPAK(Phospho Ser323) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human STK39 around the phosphorylation site of Ser325. AA range:291-340

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

59642

synonyms

STE20/SPS1-related proline-alanine-rich protein kinase; STK39; SPAK; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39