SPAG5 Antibody

Size

100ul

Clone Number

Aliases

Astrin antibody; Deepest antibody; hMAP 126 antibody; hMAP126 antibody; MAP 126 antibody; MAP126 antibody; Mitotic spindle associated protein antibody; Mitotic spindle associated protein p126 antibody; Mitotic spindle coiled coil related protein antibody; Mitotic spindle-associated protein p126 antibody; SPAG 5 antibody; SPAG5 antibody; SPAG5_HUMAN antibody; Sperm associated antigen 5 antibody; Sperm tail protein Spag 5 antibody; Sperm tail protein Spag5 antibody; Sperm-associated antigen 5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96R06

Immunogen

Recombinant Human Sperm-associated antigen 5 protein (1-300AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SPAG5

Research Areas

Cell biology