SORT1 Antibody

Size

100ug

Clone Number

Aliases

100 kDa NT receptor antibody; Glycoprotein 95 antibody; Gp 95 antibody; Gp95 antibody; LDLCQ6 antibody; Neurotensin receptor 3 antibody; NT 3 antibody; NT3 antibody; NTR 3 antibody; NTR3 antibody; OTTHUMP00000013784 antibody; SORT 1 antibody; SORT_HUMAN antibody; SORT1 (gene name) antibody; Sort1 antibody; Sortilin 1 antibody; Sortilin antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99523

Immunogen

Recombinant Human Sortilin protein (328-457AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Background

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SORT1

Research Areas

Neuroscience; Cancer; Cardiovascular; Metabolism