SORL1 Antibody

Size

100ug

Clone Number

Aliases

C11orf32 antibody; FLJ21930 antibody; FLJ39258 antibody; gp250 antibody; LDLR relative with 11 ligand binding repeats antibody; LDLR relative with 11 ligand-binding repeats antibody; Low density lipoprotein receptor relative with 11 ligand binding repeats antibody; Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody; LR 11 antibody; LR11 antibody; LRP 9 antibody; LRP9 antibody; Mosaic protein LR11 antibody; SORL 1 antibody; SORL_HUMAN antibody; SORL1 antibody; SorLA 1 antibody; SorLA antibody; SorLA-1 antibody; Sortilin related receptor antibody; Sortilin related receptor L(DLR class) A repeats containing antibody; Sortilin-related receptor antibody; Sorting protein related receptor containing LDLR class A repeats antibody; Sorting protein-related receptor containing LDLR class A repeats antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92673

Immunogen

Recombinant Human Sortilin-related receptor protein (525-744AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SORL1

Research Areas

Neuroscience; Metabolism; Signal transduction