SnoN Polyclonal Antibody

Ab type

Primary antibody

Background

Ski-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

77004

synonyms

SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein