SNAI2 Antibody

Size

100ug

Clone Number

Aliases

MGC10182 antibody; Neural crest transcription factor Slug antibody; Protein snail homolog 2 antibody; Slug (chicken homolog) zinc finger protein antibody; Slug homolog zinc finger protein antibody; Slug zinc finger protein antibody; SLUGH antibody; SLUGH 1 antibody; SLUGH1 antibody; SNAI 2 antibody; Snai2 antibody; SNAI2_HUMAN antibody; Snail 2 antibody; Snail homolog 2 antibody; Snail2 antibody; WS 2D antibody; WS2D antibody; Zinc finger protein SLUG antibody; Zinc finger protein SNAI2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O43623

Immunogen

Recombinant Human Zinc finger protein SNAI2 protein (12-124AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SNAI2

Research Areas

Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Developmental biology; Stem cells