Snaclec rhodocytin subunit alpha Antibody

Size

100ug

Clone Number

Aliases

antibody; Snaclec rhodocytin subunit alpha antibody; Aggretin alpha chain antibody; Rhodoaggretin subunit alpha antibody

Immunogen Species

Calloselasma rhodostoma

UniProt ID

Q9I841

Immunogen

Recombinant Calloselasma rhodostoma Snaclec rhodocytin subunit alpha protein (1-136AA)

Raised in

Rabbit

Species Reactivity

Calloselasma rhodostoma

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLC-gamma-2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha-2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

Research Areas

Others