SMYD2 Antibody

Size

100ug

Clone Number

Aliases

Histone methyltransferase SMYD2 antibody; HSKM B antibody; HSKM-B antibody; HSKMB antibody; KMT3C antibody; Lysine N-methyltransferase 3C antibody; MGC119305 antibody; N lysine methyltransferase SMYD2 antibody; N-lysine methyltransferase SMYD2 antibody; SET and MYND domain containing 2 antibody; SET and MYND domain containing protein 2 antibody; SET and MYND domain-containing protein 2 antibody; Smyd2 antibody; SMYD2_HUMAN antibody; Zinc finger MYND domain containing 14 antibody; ZMYND14 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NRG4

Immunogen

Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 \\\'Lys-4\\\' (H3K4me) and dimethylates histone H3 \\\'Lys-36\\\' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates \\\'Lys-370\\\' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at \\\'Lys-860\\\'.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMYD2

Research Areas

Epigenetics and Nuclear Signaling