SMC5 Antibody

Size

100ug

Clone Number

Aliases

SMC5 antibody; KIAA0594 antibody; SMC5L1 antibody; Structural maintenance of chromosomes protein 5 antibody; SMC protein 5 antibody; SMC-5 antibody; hSMC5 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8IY18

Immunogen

Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMC5

Research Areas

Epigenetics and Nuclear Signaling; Cell biology