SMC1(Phospho-Ser360) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins| SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis| although those complexes at the kinetochore remain. Therefore| the encoded protein is thought to be an important part of functional kinetochores. In addition| this protein interacts with BRCA1 and is phosphorylated by ATM| indicating a potential role for this protein in DNA repair. This gene| which belongs to the SMC gene family| is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human SMC1 (Ser360)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

SMC1 ;Ser360; Structural maintenance of chromosomes protein 1A; SMC protein 1A; SMC-1-alpha; SMC-1A; Sb1.8