SMARCD3 Antibody

Size

100ug

Clone Number

Aliases

60 kDa BRG 1/Brm associated factor subunit C antibody; 60 kDa BRG-1/Brm-associated factor subunit C antibody; BAF60C antibody; BRG1 associated factor 60C antibody; BRG1-associated factor 60C antibody; Chromatin remodeling complex BAF60C subunit antibody; CRACD3 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody; MGC111010 antibody; Rsc6p antibody; Smarcd3 antibody; SMRD3_HUMAN antibody; SWI/SNF complex 60 kDa subunit C antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody; Swp73 like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q6STE5

Immunogen

Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 protein (2-101AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMARCD3

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism; Signal transduction