SMARCD1 Antibody

Size

100ug

Clone Number

Aliases

60 kDa BRG-1/Brm-associated factor subunit A antibody; 60 kDa BRG1/Brm associated factor subunit A antibody; BAF60A antibody; BRG1 associated factor 60A antibody; BRG1-associated factor 60A antibody; Chromatin remodeling complex BAF60A subunit antibody; CRACD1 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60A antibody; Rsc6p antibody; SMARCD1 antibody; SMRD1 antibody; SMRD1_HUMAN antibody; SWI/SNF complex 60 kDa subunit A antibody; SWI/SNF complex 60 kDa subunit antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin d1 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 antibody; Swp73 like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96GM5

Immunogen

Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 protein (7-124AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMARCD1

Research Areas

Epigenetics and Nuclear Signaling; Signal transduction