SMAD4 Antibody

Size

150ul

Clone Number

Aliases

(Small) Mothers Against Decapentaplegic antibody; Deleted in Pancreatic Carcinoma 4 antibody; Deleted in Pancreatic Carcinoma antibody; Deleted in pancreatic carcinoma locus 4 antibody; Deletion target in pancreatic carcinoma 4 antibody; DPC 4 antibody; DPC4 antibody; hSMAD4 antibody; JIP antibody; MAD homolog 4 antibody; MAD mothers against decapentaplegic Drosophila homolog 4 antibody; MAD mothers against decapentaplegic homolog 4 antibody; MADH 4 antibody; MADH4 antibody; Med antibody; Medea antibody; Mothers against decapentaplegic homolog 4 antibody; Mothers against decapentaplegic; Drosophila; homolog of; 4 antibody; Mothers against DPP homolog 4 antibody; MYHRS antibody; OTTHUMP00000163548 antibody; SMA- and MAD-related protein 4 antibody; SMAD 4 antibody; SMAD family member 4 antibody; SMAD mothers against DPP homolog 4 antibody; SMAD4 antibody; SMAD4_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13485

Immunogen

Recombinant Human Mothers against decapentaplegic homolog 4 protein

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC

Background

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5\'-GTCT/AGAC-3\') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMAD4

Research Areas

Epigenetics and Nuclear Signaling;Cancer?Cardiovascular;Metabolism;Signal transduction?Stem cells