SMAD2 Monoclonal Antibody

Size

Clone Number

Aliases

hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;

Immunogen Species

Human

UniProt ID

Q15796

Immunogen

Purified recombinant human SMAD2 protein fragments expressed in E.coli.

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200

Background

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity purified

Conjugate

Non-conjugated

Buffer

Ascites

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SMAD2

Research Areas

Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction?Stem cells