Smad1(Phospho Ser214) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).|PTM:Phosphorylated on serine by BMP type 1 receptor kinase.|PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.|Belongs to the dwarfin/SMAD family.|Contains 1 MH1 (MAD homology 1) domain.|Contains 1 MH2 (MAD homology 2) domain.|subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.|subunit:Interacts with HGS| NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit| CREB-binding protein (CBP)| p300| SMURF1| SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.|tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.|

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human Smad1 (Phospho Ser214)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

51150

synonyms

Smad1 ;Phospho Ser214; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1