SLC3A2 Antibody

Size

100ul

Clone Number

Aliases

4F2 antibody; 4F2 cell surface antigen heavy chain antibody; 4F2 cell-surface antigen heavy chain antibody; 4F2 heavy chain antibody; 4F2 heavy chain antigen antibody; 4F2_HUMAN antibody; 4F2hc antibody; 4T2HC antibody; Antigen defined by monoclonal antibody 4F2 heavy chain antibody; Antigen identified by monoclonal antibodies 4F2 TRA1.10 TROP4 and T43 antibody; CD 98 antibody; CD98 antibody; CD98 antigen antibody; CD98 heavy chain antibody; CD98HC antibody; Heavy chain antibody; Lymphocyte activation antigen 4F2 large subunit antibody; MDU 1 antibody; MDU1 antibody; Monoclonal antibody 44D7 antibody; NACAE antibody; Slc3a2 antibody; Solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2 antibody; Solute carrier family 3 member 2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P08195

Immunogen

Recombinant Human 4F2 cell-surface antigen heavy chain protein (404-630AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB; Recommended dilution: WB:1:1000-1:5000

Background

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SLC3A2

Research Areas

Cancer; Immunology; Metabolism; Signal transduction; Stem cells