SKA1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

2810433K01Rik antibody; AV117428 antibody; C18orf24 antibody; MGC10200 antibody; Ska1 antibody; SKA1_HUMAN antibody; Spindle and kinetochore associated complex subunit 1 antibody; Spindle and kinetochore associated protein 1 antibody; Spindle and kinetochore-associated protein 1 antibody; Spindle and KT (kinetochore) associated 1 antibody; Spindle and KT associated 1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96BD8

Immunogen

Recombinant Human Spindle and kinetochore-associated protein 1 protein (61-134AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SKA1

Research Areas

Cell biology