SIX1 Antibody

Size

100ug

Clone Number

Aliases

BOS3 antibody; DFNA23 antibody; Homeobox protein SIX1 antibody; OTTHUMP00000179042 antibody; Sine oculis homeobox homolog 1 antibody; SIX homeobox 1 antibody; SIX1 antibody; SIX1_HUMAN antibody; TIP39 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15475

Immunogen

Recombinant Human Homeobox protein SIX1 protein (144-262AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5\\\'-TCA[AG][AG]TTNC-3\\\' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SIX1

Research Areas

Epigenetics and Nuclear Signaling; Cancer