SIRT6 Antibody

Size

100ul

Clone Number

Aliases

2810449N18Rik antibody; AI043036 antibody; Mono ADP ribosyltransferase sirtuin 6 antibody; NAD-dependent protein deacetylase sirtuin-6 antibody; Regulatory protein SIR2 homolog 6 antibody; Regulatory protein SIR2 homolog antibody; SIR2 like 6 antibody; SIR2 like protein 6 antibody; Sir2 related protein type 6 antibody; SIR2-like protein 6 antibody; SIR2L6 antibody; SIR6_HUMAN antibody; SIRT 6 antibody; SIRT6 antibody; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody; Sirtuin 6 antibody; Sirtuin type 6 antibody; Sirtuin6 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8N6T7

Immunogen

Recombinant Human NAD-dependent protein deacetylase sirtuin-6 protein (1-355AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SIRT6

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Cardiovascular; Metabolism; Signal transduction