SIGMAR1 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

Aging associated gene 8 protein antibody; Aging-associated gene 8 protein antibody; AL024364 antibody; hSigmaR1 antibody; mSigmaR1 antibody; opioid receptor, sigma 1 antibody; opioid receptor, sigma 1 isoform 1 antibody; RP23 167I12.6 antibody; SGMR1_HUMAN antibody; SIG 1R antibody; SIG-1R antibody; Sigma 1-type opioid receptor antibody; Sigma non-opioid intracellular receptor 1 antibody; sigma1 receptor antibody; Sigma1-receptor antibody; Sigma1R antibody; Sigmar1 antibody; SR BP antibody; SR-BP antibody; SR31747 binding protein antibody; SR31747-binding protein antibody; SRBP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q99720

Immunogen

Recombinant Human Sigma non-opioid intracellular receptor 1 protein (112-169AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SIGMAR1

Research Areas

Others