SHP-2(Phospho-Tyr542) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. This PTP contains two tandem Src homology-2 domains| which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions| such as mitogenic activation| metabolic control| transcription regulation| and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human SHP-2 (Tyr542)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

SHP-2 ;Tyr542; Tyrosine-protein phosphatase non-receptor type 11; EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3