SHP-1(Phospho-Tyr564) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains| which act as protein phospho-tyrosine binding domains| and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells| and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with| and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene| which encode distinct isoforms| have been reported.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human SHP-1 (Tyr564)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

SHP-1 ;Tyr564 ; Tyrosine-protein phosphatase non-receptor type 6; EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1