SHIP-1 Polyclonal Antibody

Ab type

Primary antibody

Background

INPP5D is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes inositol polyphosphate-5-phosphatase D with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of inositol polyphosphate-5-phosphatase D is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Inositol polyphosphate-5-phosphatase D is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in INPP5D are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human SHIP1. AA range:1140-1189

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

133193

synonyms

INPP5D; SHIP; SHIP1; Phosphatidylinositol 3; 4,5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-co