SHC1 Antibody

Size

100ug

Clone Number

Aliases

FLJ26504 antibody; p66 antibody; p66SHC antibody; SH2 domain protein C1 antibody; SHC (Src homology 2 domain containing) transforming protein 1 antibody; SHC 1 antibody; SHC A antibody; SHC adaptor protein 1 antibody; Shc antibody; SHC transforming protein 1 antibody; SHC transforming protein antibody; SHC-transforming protein 1 antibody; SHC-transforming protein 3 antibody; SHC-transforming protein A antibody; SHC1 antibody; SHC1_HUMAN antibody; SHCA antibody; Src homology 2 domain-containing-transforming protein C1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P29353

Immunogen

Recombinant Human SHC-transforming protein 1 protein (207-370AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SHC1

Research Areas

Neuroscience; Signal transduction