SH2D1A Antibody

Size

100ug

Clone Number

Aliases

DSHP antibody; Duncan disease SH2 protein antibody; Duncan disease SH2-protein antibody; EBVS antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; SAP/SH2D1A antibody; SH2 domain containing 1A antibody; SH2 domain protein 1A antibody; SH2 domain-containing protein 1A antibody; SH21A_HUMAN antibody; SH2D1A antibody; Signaling lymphocyte activation molecule associated protein antibody; Signaling lymphocytic activation molecule-associated protein antibody; SLAM associated protein antibody; SLAM associated protein/SH2 domain protein 1A antibody; SLAM-associated protein antibody; T cell signal transduction molecule SAP antibody; T-cell signal transduction molecule SAP antibody; XLP antibody; XLPD antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O60880

Immunogen

Recombinant Human SH2 domain-containing protein 1A protein (11-124AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SH2D1A

Research Areas

Cardiovascular; Immunology