SGMS1 Antibody

Size

100ug

Clone Number

Aliases

SGMS1 antibody; MOB antibody; SMS1 antibody; TMEM23 antibody; Phosphatidylcholine:ceramide cholinephosphotransferase 1 antibody; EC 2.7.8.27 antibody; Medulla oblongata-derived protein antibody; Protein Mob antibody; Sphingomyelin synthase 1 antibody; Transmembrane protein 23 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86VZ5

Immunogen

Recombinant Human Phosphatidylcholine:ceramide cholinephosphotransferase 1 protein (48-137AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SGMS1

Research Areas

Cancer; Metabolism; Signal transduction