SFRP1 Antibody

Size

100ug

Clone Number

Aliases

Frizzled related protein 1 antibody; FRP 1 antibody; FRP antibody; FRP-1 antibody; FRP1 antibody; FrzA antibody; SARP 2 antibody; SARP-2 antibody; SARP2 antibody; Secreted apoptosis related protein 2 antibody; Secreted apoptosis-related protein 2 antibody; Secreted frizzled related protein 1 antibody; Secreted frizzled related protein antibody; Secreted frizzled-related protein 1 antibody; SFRP 1 antibody; sFRP-1 antibody; SFRP1 antibody; SFRP1_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q8N474

Immunogen

Recombinant Human Secreted frizzled-related protein 1 protein (170-240AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000, IF:1:50-1:500

Background

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SFRP1

Research Areas

Neuroscience; Cell biology; Developmental biology; Stem cells