SF3B2 Antibody

Size

100ul

Clone Number

Aliases

SF3B2 antibody; SAP145 antibody; Splicing factor 3B subunit 2 antibody; Pre-mRNA-splicing factor SF3b 145 kDa subunit antibody; SF3b145 antibody; Spliceosome-associated protein 145 antibody; SAP 145 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q13435

Immunogen

Recombinant Human Splicing factor 3B subunit 2 protein (616-895AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Subunit of the splicing factor SF3B required for \\\'A\\\' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the \\\'E\\\' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SF3B2

Research Areas

Epigenetics and Nuclear Signaling