SF3B1(Phospho-Thr313) Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b| together with splicing factor 3a and a 12S RNA unit| forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical| tandem HEAT repeats that form rod-like| helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phosho peptide around human SF3B1 (Thr313)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

SF3B1 ;Thr313 ; Splicing factor 3B subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155