SETDB1 Antibody

Size

100ul

Clone Number

Aliases

AU022152 antibody; EC 2.1.1.43 antibody; ERG-associated protein with SET domain antibody; ESET antibody; H3 K9 HMTase 4 antibody; H3-K9-HMTase 4 antibody; H3-K9-HMTase4 antibody; Histone H3 K9 methyltransferase 4 antibody; Histone H3-K9 methyltransferase 4 antibody; Histone-lysine N-methyltransferase SETDB1 antibody; KG1T antibody; KIAA0067 antibody; KMT1E antibody; Lysine N-methyltransferase 1E antibody; MGC90670 antibody; mKIAA0067 antibody; SET domain bifurcated 1 antibody; Set domain protein; bifurcated; 1 antibody; SETB1_HUMAN antibody; Setdb1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q15047

Immunogen

Recombinant Human Histone-lysine N-methyltransferase SETDB1 protein (1-397AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Histone methyltransferase that specifically trimethylates \\\'Lys-9\\\' of histone H3. H3 \\\'Lys-9\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 \\\'Lys-9\\\' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone \\\'Lys-9\\\' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SETDB1

Research Areas

Epigenetics and Nuclear Signaling