SESN1 Antibody

Size

100ug

Clone Number

Aliases

1110002G11Rik antibody; AU044290 antibody; MGC118148 antibody; MGC138241 antibody; MGC142129 antibody; OTTMUSP00000022799 antibody; p53 activated gene 26 antibody; p53 regulated PA26 nuclear protein antibody; p53 regulated protein PA26 antibody; p53-regulated protein PA26 antibody; PA26 antibody; RP11-787I22.1 antibody; sesn1 antibody; SESN1_HUMAN antibody; SEST1 antibody; sestrin 1 antibody; Sestrin-1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y6P5

Immunogen

Recombinant Human Sestrin-1 protein (224-337AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SESN1

Research Areas

Cell biology; Metabolism