SENP1 Antibody

Size

100ug

Clone Number

Aliases

SENP 1 antibody; SENP1 antibody; SENP1_HUMAN antibody; Sentrin specific protease 1 antibody; Sentrin-specific protease 1 antibody; Sentrin/SUMO specific protease 1 antibody; Sentrin/SUMO specific protease antibody; Sentrin/SUMO specific protease SENP 1 antibody; Sentrin/SUMO specific protease SENP1 antibody; Sentrin/SUMO-specific protease SENP1 antibody; SUMO1/sentrin specific peptidase 1 antibody; SUMO1/sentrin specific protease 1 antibody; SuPr 2 antibody; SuPr2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9P0U3

Immunogen

Recombinant Human Sentrin-specific protease 1 protein (63-214AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SENP1

Research Areas

Epigenetics and Nuclear Signaling; Cell biology