SEMA4D Antibody

Size

100ug

Clone Number

Aliases

A8 antibody; BB 18 antibody; BB18 antibody; CD 100 antibody; CD100 antibody; CD100 antigen antibody; Coll 4 antibody; COLL4 antibody; Collapsin 4 antibody; Collapsin4 antibody; GR3 antibody; Leukocyte activation antigen CD100 antibody; M sema G antibody; MSEMA antibody; SEM4D_HUMAN antibody; Sema 4d antibody; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4D antibody; Sema H antibody; SEMA J antibody; Sema4d antibody; Semacl 2 antibody; Semacl2 antibody; SemaH antibody; SEMAJ antibody; Semaphorin 4D antibody; Semaphorin C like 2 antibody; Semaphorin H antibody; Semaphorin J antibody; Semaphorin-4D antibody; Semaphorin4D antibody; SemaphorinJ antibody; Semcl 2 antibody; Semcl2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92854

Immunogen

Recombinant Human Semaphorin-4D protein (756-862AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SEMA4D

Research Areas

Neuroscience; Immunology