SELENON Antibody

Size

100ug

Clone Number

Aliases

CFTD antibody; MDRS1 antibody; RSMD1 antibody; RSS antibody; Selenoprotein N antibody; Selenoprotein N, 1 antibody; SelN antibody; SELN_HUMAN antibody; sepn1 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NZV5

Immunogen

Recombinant Human Selenoprotein N protein (135-219AA)

Raised in

Rabbit

Species Reactivity

Human, Rat

Tested Applications

ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background

Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SELENON

Research Areas

Others