SDCBP Antibody, Biotin conjugated

Size

100ug

Clone Number

Aliases

MDA-9 antibody; MDA9 antibody; Melanoma differentiation-associated protein 9 antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody; Scaffold protein Pbp1 antibody; SDCB1_HUMAN antibody; SDCBP antibody; ST1 antibody; SYCL antibody; Syndecan binding protein (syntenin) antibody; Syndecan binding protein 1 antibody; Syndecan-binding protein 1 antibody; Syntenin 1 antibody; Syntenin-1 antibody; TACIP18 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00560

Immunogen

Recombinant Human Syntenin-1 protein (21-228AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Biotin

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SDCBP

Research Areas

Neuroscience