SAV1 Antibody

Size

100ul

Clone Number

Aliases

1700040G09Rik antibody; 45 kDa WW domain protein antibody; hWW 45 antibody; hWW45 antibody; Protein salvador homolog 1 antibody; salvador family WW domain containing protein 1 antibody; salvador homolog 1 (Drosophila) antibody; Salvador homolog 1 antibody; Salvador, Drosophila, homolog of antibody; SAV 1 antibody; SAV antibody; SAV1 antibody; SAV1_HUMAN antibody; WW 45 antibody; WW domain containing antibody; WW domain-containing adaptor 45 antibody; WW domain-containing protein, 45-KD antibody; WW45 antibody; WW45 protein antibody; WWP 4 antibody; WWP4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H4B6

Immunogen

Recombinant Human Protein salvador homolog 1 protein (1-210AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200

Background

Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SAV1

Research Areas

Signal transduction