SARM1 Polyclonal Antibody

Ab type

Primary antibody

Background

Was initially reported to contain ARM repeats (PubMed:11386760). Such repeats are however not predicted by any detection method.,Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.,Contains 1 TIR domain.,Contains 2 SAM (sterile alpha motif) domains.,subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function.,tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.,

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human protein . at AA range: 281-330

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

Sterile alpha and TIR motif-containing protein 1 ;Sterile alpha and Armadillo repeat protein;Sterile alpha motif domain-containing protein 2;SAM domain-containing protein 2;Tir-1 homolog