SAMHD1 Antibody

Size

100ul

Clone Number

Aliases

CHBL2 antibody; DCIP antibody; Dendritic cell derived IFNG induced protein antibody; Dendritic cell-derived IFNG-induced protein antibody; Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 antibody; dNTPase antibody; HD domain containing 1 antibody; HDDC1 antibody; Mg11 antibody; Monocyte protein 5 antibody; MOP 5 antibody; MOP-5 antibody; MOP5 antibody; OTTHUMP00000030889 antibody; SAM domain and HD domain 1 antibody; SAM domain and HD domain containing protein 1 antibody; SAM domain and HD domain-containing protein 1 antibody; SAMH1_HUMAN antibody; Samhd1 antibody; SBBI88 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y3Z3

Immunogen

Recombinant Human Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 protein (1-314AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:100-1:500

Background

Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur. Blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May play a role in mediating proinflammatory responses to TNF-alpha signaling (PubMed:18546154, PubMed:19525956, PubMed:22056990, PubMed:24336198, PubMed:28229507). Has ribonuclease activity, acting on single-stranded RNA. This activity is essential for H1V-1 restriction (PubMed:25038827).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Antigen Affinity purified & Affinity purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SAMHD1

Research Areas

Signal Transduction