SAMD8 Antibody

Size

100ug

Clone Number

Aliases

SAMD8Sphingomyelin synthase-related protein 1 antibody; SMSr antibody; EC 2.7.8.- antibody; Ceramide phosphoethanolamine synthase antibody; CPE synthase antibody; Sterile alpha motif domain-containing protein 8 antibody; SAM domain-containing protein 8 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96LT4

Immunogen

Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

SAMD8

Research Areas

Cancer; Cell biology; Metabolism; Signal transduction