RYR2 Antibody

Size

100ug

Clone Number

Aliases

ARVC2 antibody; ARVD2 antibody; Cardiac muscle ryanodine receptor antibody; Cardiac muscle ryanodine receptor-calcium release channel antibody; hRYR-2 antibody; ryanodine receptor 2 (cardiac) antibody; Ryanodine receptor 2 antibody; RyR antibody; RYR-2 antibody; RyR2 antibody; RYR2_HUMAN antibody; Type 2 ryanodine receptor antibody; VTSIP antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q92736

Immunogen

Recombinant Human Ryanodine receptor 2 protein (901-1192AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RYR2

Research Areas

Neuroscience; Cancer; Cardiovascular; Metabolism; Signal transduction