RYK Antibody

Size

100ug

Clone Number

Aliases

D3S3195 antibody; ERK 3 antibody; Hydroxyaryl protein kinase antibody; JTK 5 antibody; JTK 5A antibody; JTK5 antibody; JTK5A antibody; JTK5A protein tyrosine kinase antibody; receptor like tyrosine kinase antibody; receptor like tyrosine kinase precursor antibody; RYK 1 antibody; Ryk antibody; RYK_HUMAN antibody; RYK1 antibody; Tyrosine protein kinase RYK antibody; Tyrosine protein kinase RYK precursor antibody; Tyrosine-protein kinase RYK antibody; Vik antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P34925

Immunogen

Recombinant Human Tyrosine-protein kinase RYK protein (494-586AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500

Background

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RYK

Research Areas

Signal transduction; Stem cells