RUNX3 Polyclonal Antibody

Ab type

Primary antibody

Background

RUNX3 (runt related transcription factor 3) encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and RUNX3 is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human RUNX3.

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

44356

synonyms

RUNX3; AML2; CBFA3; PEBP2A3; Runt-related transcription factor 3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; CBF-alpha-3; Oncogene AML-2; Polyomavirus enhancer-binding prot