RTN4RL2 Antibody

Size

100ul

Clone Number

Aliases

RTN4RL2 antibody; NGRH1 antibody; NGRL3 antibody; Reticulon-4 receptor-like 2 antibody; Nogo receptor-like 3 antibody; Nogo-66 receptor homolog 1 antibody; Nogo-66 receptor-related protein 2 antibody; NgR2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q86UN3

Immunogen

Peptide sequence from Human Reticulon-4 receptor-like 2 protein (355-372AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed: 22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed: 22325200).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RTN4RL2

Research Areas

Neuroscience