RTEL1 Antibody

Size

100ug

Clone Number

Aliases

RTEL1 antibody; C20orf41 antibody; KIAA1088 antibody; NHLRegulator of telomere elongation helicase 1 antibody; EC 3.6.4.12 antibody; Novel helicase-like antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NZ71

Immunogen

Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RTEL1

Research Areas

Epigenetics and Nuclear Signaling