RRM2B Antibody

Size

100ul

Clone Number

Aliases

DKFZp686M05248 antibody; MGC102856 antibody; MGC42116 antibody; MTDPS8A antibody; MTDPS8B antibody; p53 inducible ribonucleotide reductase small subunit 2 homolog antibody; p53 inducible ribonucleotide reductase small subunit 2 like protein antibody; P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody; p53 R2 antibody; p53-inducible ribonucleotide reductase small subunit 2-like protein antibody; p53R2 antibody; Ribonucleoside diphosphate reductase M2 subunit B antibody; Ribonucleoside-diphosphate reductase subunit M2 B antibody; Ribonucleotide reductase M2 B (TP53 inducible) antibody; Ribonucleotide reductase M2 B antibody; Ribonucleotide reductase small subunit like 2 p53 inducible antibody; RIR2B_HUMAN antibody; RRM 2B antibody; RRM2B antibody; TP53 inducible ribonucleotide reductase M2 B antibody; TP53-inducible ribonucleotide reductase M2 B antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q7LG56

Immunogen

Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IP; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000

Background

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

RRM2B

Research Areas

Epigenetics and Nuclear Signaling; Cancer; Metabolism