MYDGF Antibody / Myeloid-derived growth factor

Human MYDGF, also called Myeloid-derived growth factor, Stromal cell-derived growth factor SF20 and C19orf10, and formerly known as IL25, is a bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction. MYDGF stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1 mediated signaling pathway. It is thought to inhibit cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway and is involved in endothelial cell proliferation and angiogenesis.