MSX2 Antibody / Hox-8

Homeobox protein MSX-2, also called Homeobox protein Hox-8 (Hox8) is a protein that in humans is encoded by the MSX2 gene. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.