Ark-1 Antibody / Aurora-related kinase 1 / Aurka

AURKA (Aurora kinase A), also called ARK-1 (Aurora-related kinase 1), AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15, and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA/ARK-1 in tumor development is in controlling chromosome segregation during mitosis. Aurora A / Aurora-related kinase 1 is a member of a family of mitotic serine/threonine kinases. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53.