RCC1 Antibody / Regulator of Chromosome Condensation

Regulator of Chromosome Condensation, also named RCC1, SNHG3-RCC1 and CHC1 (Chromosome condensation protein 1), promotes the exchange of ran-bound gdp by gtp. It is involved in the regulation of onset of chromosome condensation in the S-phase. Phosphorylation of RCC1 on serines located in or near its nuclear localization signal activates RCC1 to generate RanGTP on mitotic chromosomes, which is required for spindle assembly and chromosome segregation.